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Author Topic: Update on Doc Holliday  (Read 1468 times)

Bulldogger

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Update on Doc Holliday
« on: November 15, 2010, 09:33:58 PM »

Well, we spent most of the afternoon at the vet with Doc.  Just took a long time to get checked and discuss our plan of action.  Below is a run down.

Doc did seem to be coughing more last night and today and his eyes were definitely bloodshot, however today at the vets...

Checked Doc's temp and it was great.. no fever at all.
Checked lymph nodes and none were swollen, all normal.
Aspirated a lymph node and it was ok, they didn't find anything.
Took a sample from one of the lesions again and checked it, but didn't find anything.  (although I had used my homemade spray on his skin lesions day before yesterday with gentian violet in it, which is an old time antifungal, so if there was any sign of blasto there, I may have negated the skin sample).

I talked with the vet about the Mira Vista urine test.  She had no experience with Mira Vista and said they have their own lab that might offer the same type testing, but it would probably cost $150 for the urine test.  She didn't seem to put a lot of faith in the blood or urine testing for blasto, but I told her to go ahead with the urine test, but I requested that they use Mira Vista and send the sample to them for the testing.  She said if there was a cost offset, they would credit me back incase the test wasn't as expensive with Mira Vista, so I certainly couldn't complain with that.

We then discussed meds.  She wanted to put Doc on another round of antibiotics, but I politely declined.  I really couldn't see any reason for it, as he had already been on a good dose of cephelaxin and if he had anything bacterial, I'm thinking it should have already cleared up.  We discussed antifungals and she suggested the ketoconazole, but I told her I wanted to put Doc on fluconazole instead.  She was ok with it and prescribed what she called a middle of the road dosage.  Only thing is, what she came up with seems to be a little on the high end, if I am figuring everything correctly.  We re-weighed Doc again and he has actually lost back to 109lbs.

Merck Vet Manual has the fluconazole dosage at 2.5 - 10 mg/kg sid (once daily).  

She basically prescribed 1000mg per day for Doc.  The highest mg fluconazole (from Walmart) comes in is 200mg, so she prescribed two and 1/2 tablets of 200mg fluconazole twice daily for 10 days.  At that time, we will re-evaluate and go from there.  

I guess my question to those who have dogs on fluconazole, does this sound right??  I guess a 1000mg just seems like a lot, but may be it's not.  Just wondering if this sounds about right for his size?

The vets are great, don't get me wrong, but they go from patient to patient.  They aren't sitting there dwelling on blasto, researching or brainstorming like a concerned owner would be.  Many have never even seen blasto and those that have, may or may not be up to date on all the latest.  In a busy vet practice, I can understand.

It may just be my paranoia, but I kinda got that impression when I asked about the Mira Vista testing.  You could kinda see a frown or two crop up, even though they accomodated us and did the test for us.  While I wouldn't go as far as to say they were reluctant about anything, they just seemed like it was a little on the tedious side.  Like I said though, it may just be me.  They did do what I asked them to, so I am greatful that they at least listened.  

I am getting ready to give Doc his first dose of fluconazole here shortly.

Thanks in advance for any suggestions or comments,
Lou
« Last Edit: November 16, 2010, 12:28:21 PM by Bulldogger »
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evayola

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Re: Update on Doc Holliday
« Reply #1 on: November 15, 2010, 10:42:03 PM »

Marge weighs around 140-150 lbs and the highest dose of fluconazole that she was ever on was 300mg 2x day. I'm glad to hear that your vet is willing to listen and do as you please. 1000 mg though is much much too high for him. Keep your head and spirits up and give Doc a hug for me.
Eva
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Cathy, Bailey and Duke

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Re: Update on Doc Holliday
« Reply #2 on: November 15, 2010, 10:54:19 PM »

The vets in the Kenora, Ontario area are really knowledgeable in blasto. It is really a hot spot. As for dosage, mabe your vet can call them. They are really good about taking time for pets with blasto in other areas Here is their info.

Kenora Veterinary Clinic
Place page
305 Matheson Street South
Kenora, ON P9N 1V4
(807) 468-7441

Hope Doc continues to be on the up and up.

Bulldogger

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Re: Update on Doc Holliday
« Reply #3 on: November 15, 2010, 11:19:11 PM »

Thanks so much for the encouragment and info guys.  It is much appreciated.  I thought the 1000mg sounded high!  I also notice something on the Merck site with the dosage for fluconazole and it says  2.5mg - 10mg/kg sid (sid stands for once daily), so if you figure up the dosage for Doc's weight of 109lbs, it would come out to be 500mg once daily.  Since fluconazole is given twice daily, it should really be more like 250mg twice daily = 500mg total. 

Well, I'm going to go by my gut instinct here and give him 250mg twice daily to = 500mg because I really don't feel comfortable giving him a 1000mg total dose.  If Marge only was getting 600mg total and she's bigger than him, the higher dose of 1000mg might send him into liver failure or worse.  Did you notice anything in the way of side effects after the first couple of doses of fluconazole with Marge?

Thanks Kathy, Bailey and Duke for the info.  I was just talking about blasto areas with my husband a little while ago and he was asking me what area's were more specific to it.

 
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Sadie123

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Re: Update on Doc Holliday
« Reply #4 on: November 15, 2010, 11:27:36 PM »

Sadie's urine test came back negative for blasto, but we started Fluco as soon as they saw the chest x-ray.  She is 53 lbs and is taking 200 mg bid.  The cost of her test was $144.  I don't know the break down but my charge included overnight shipping to Mira Vista.  Even though the test came back negative for blasto we are staying on the fluco until she wither improves, declines, or we can find another cause for her chest x-ray (snowflake pattern).  

Good Luck with your efforts and best wishes to Doc for a healthy recovery.    :)
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Cathy, Bailey and Duke

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Re: Update on Doc Holliday
« Reply #5 on: November 15, 2010, 11:29:15 PM »

When most dogs go on the meds, they get quite a bit worse before they get better. We practically had to carry Duke out to go to the bathroom. Just keep them eating and drinking, even force feed with a turkey baster (liquids) and the vets also have a tube of gel that has all kinds of vitamins and other nutrients you can get them to swallow.

benniesmom

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Re: Update on Doc Holliday
« Reply #6 on: November 15, 2010, 11:39:07 PM »

oh man. that really sounds too high. WAY too high, the vet's plan..........you might want to do your own math using the Merck specs/. I think that's what you are doing! The Mira Vista test here was $115.50, and ithe results do take a while. Ours was last Monday and it isn't back yet.......We have lots of Blasto here, lots..... so Fluco, Mira Vista, it's all standard...... And that dose is outta sight..Go with your gut feleling!!!
Ben is doing well!

We're thinking of you.....
Bar and Ben

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Cathy, Bailey and Duke

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Re: Update on Doc Holliday
« Reply #7 on: November 15, 2010, 11:41:12 PM »

Where are you in Northern Minnesota?

oh man. that really sounds too high. WAY too high, the vet's plan..........you might want to do your own math using the Merck specs/. I think that's what you are doing! The Mira Vista test here was $115.50, and ithe results do take a while. Ours was last Monday and it isn't back yet.......We have lots of Blasto here, lots..... so Fluco, Mira Vista, it's all standard...... And that dose is outta sight..Go with your gut feleling!!!
Ben is doing well!

We're thinking of you.....
Bar and Ben


Sadie123

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Re: Update on Doc Holliday
« Reply #8 on: November 15, 2010, 11:44:18 PM »

Wow, all of you have such a long wait on your urine tests?  We sent Sadie's out on Wednesday and the vet started calling Friday afternoon and the results were in.  My vet charged me $144 which included an overnight shipping charge.  He told me that they were set up to have the results e-mailed to him, but that if you start calling them, you can usually get the results done faster.  We should get this out there.  You can request to have your specimen sent overnight.  Might cost you more, but we sent urine on Wednesday and got results on Friday.  I hate it that some of you are waiting over a week for results.  
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Bulldogger

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Re: Update on Doc Holliday
« Reply #9 on: November 15, 2010, 11:51:30 PM »

You guys are all so AWESOME as is this site!  My thoughts and prayers are right back at each and everyone of you! I wish everyone of us success at beating this insidious blasto!!!  I just can't get over all the horrible things this disease does to our beloved dogs!  

Oh before I forget, thought I'd share my website on my dogs.. Doc, his wife & kids LOL.  Just to forwarn you, it hasn't been updated in a long, long time.  It's through Go Daddy and they no longer offer the package I have, as they upgraded their system.  I haven't updated my site because when I do, I will have to go with a whole new format and I haven't taken the time to re-do it yet.  

www.sayloramericanbulldogs.com  
« Last Edit: November 15, 2010, 11:53:52 PM by Bulldogger »
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Norina

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Re: Update on Doc Holliday
« Reply #10 on: November 16, 2010, 06:47:13 AM »

Hope you have figured out the right dose. If I were you I would talk to the vets in Kenora if you are worried..Truly, I think the hot spot is around where Kenora is and myself. I live in the Rainy River area and have had to do this too many times. Dex is okay. Still waiting on the urine test. Will know by Thursday but really that is such a moot point now. I have noticed some swelling in his leg and yesterday he didn't even greet me at the door. Had to go and seek him out. Oh yeah... the urine test cost 185. Dex is on an antibiotic and sporonox.Thinking of all you!!!!Go Doc go!!!!!!!
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benniesmom

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Re: Update on Doc Holliday
« Reply #11 on: November 16, 2010, 07:45:56 AM »

We are in Duluth, right on the Bagley Nature Center woods, near the university. Hartley Nature center is the same woods, on the other side of Arrowhead Road. that's where lots of people walk their dogs. both places, tons of dog walkers on the trails out my windows.... and there is a lot of Blasto coming from Hartley'.
« Last Edit: November 16, 2010, 07:48:05 AM by benniesmom »
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benniesmom

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Re: Update on Doc Holliday
« Reply #12 on: November 16, 2010, 07:54:33 AM »

I looked at your website. your dogs are so so handsome and dear looking. I have a great love for the bullie breeds, and think your dogs are wonderful. Love the puppy contract.......
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apope43

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Re: Update on Doc Holliday
« Reply #13 on: November 16, 2010, 01:34:04 PM »

I think everyone's already said what I would say, but I'll add it anyway.

MiraVista cost us $125 to overnight the sample.  We sent it Friday, vet called Monday and they gave us the results.  Don't be afraid to push! Also, they are currently the ONLY lab the in country doing such a highly specific urine test.  Don't let the 'we have our own lab' talk fool you.  The only way to confirm locally for blasto is to look in the lesions, and infected eye, or an aspiration from a lung or lymph node -- and the crazy thing about blasto is that it could appear in all of those places or none of those places, and checking by the naked eye (which I would bet money is what they're doing) is not always going to be accurate.

Now, to the fluconazole.  1000mg is likely too high.  Izzy is holding steady at 72lbs, and is on 700mg a day (divided into two doses).  That may seem high, but we wanted to throw everything at it to be sure she had no more involvement in her lungs and that we kept it out of her eye.  She has also been recovering from two surgeries (eye and spay), so the vet wanted to sterilize the blasto to stop it from reproducing immediately to prevent additional infections in those areas. 

Don't mix the Diflucan with the antibiotics.  Your gut is right, she would have already reacted on the Cephalexin if it was bacterial unless it's something far beyond medical science.

I am blessed to have a vet who has spent those hours researching, developing, and checking the vet boards for blasto information.  I hate to send people his way, but please feel free to call the office of a US NATIONAL BLASTO SPECIALIST named Al Legendre down here in Tennessee.  He is currently working on a vaccine, has consulted with MiraVista and hundreds of vets along the way.  If they continue to give you trouble at the vet, call his office and ask if they know anyone in your area who has dealt with confirmed cases of blasto, and get Doc in.  His website is here:

http://www.vet.utk.edu/faculty/legendre.php

My prayer is that Doc is not battling blasto but something much more manageable.  Until then- don't be afraid to push back.  This is your dog, not another case.  We're WITH YOU!
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Niners

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Re: Update on Doc Holliday
« Reply #14 on: November 16, 2010, 02:23:18 PM »

Oh, hurry up please on that vaccine!

So glad to know someone is working on that.

ct
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