Oh this is dreadful news. We are so wanting to hear good progress for you and your family! I have been told by so many that this disease has so many ups and down -- and the downs are really really bad. It is, therefore, impossible to know what to make of all this, isn't it? Except that it's nothing good. I learned from Retriever Training forum where folks are tracking Comet's progress, as well, that one retriever (lab) lost both his eyes but survived. The poor dog was not eating, limping, in so much pain, and they had made an appointment to put him down because they just had no hope. As they put him to bed that night, the owner told him that he was so scared to lose him but did not want him to hurt any more, so he asked the dog to just give him a sign what to do. The next day his wife called him at work and told him the dog was playing with the ball (blind) and running in the back yard! He was not on any treatment at that point and had been on the brink of death for what seemed like forever but was probably days. So, they started Itra immediately, removed the two blind eyes, and they have their dog back -- after a long recuperation. Actually, he's still on Itra (since last March). So, don't give up!!! You have to be sick with worry and exhausted. I only had the round the clock vigil for a week or so, and our whole family is still exhausted!!!