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Author Topic: Beau relapses: Blasto mass in abdomen  (Read 2180 times)

lisamarr

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Beau relapses: Blasto mass in abdomen
« on: February 09, 2009, 06:38:57 AM »

Beau is battling  Blastomycosis again.  This time, it is in his abdomen, not lungs/skin.
 (Beau's a 4 and ˝ y/o Collie/ Australian cattle dog X in Ohio)

Apparently, the blasto hid in his abdomen, not being eradicated despite 10+ months on Itraconazole (brand and generic – no compounded… even the generic by EON had little spheres in the capsules).
He was off meds from late September 2007.  On 2/5/09, an abdominal ultrasound showed a mass in the upper abdomen associated with the pancreas: the specialist looked at the cytology himself and thought it was blasto, but he wouldn't rx Itraconazole until the official pathology came back… The official results came back 2/7/09, and he started itraconazole again.  The waiting was hard--- Me, I wanted him to be on meds ASAP, figuring we were playing with a time bomb!
Beau's blood work is much wackier than in 2006 with his first diagnosis…I hope his liver tolerates the med, as 1 enzyme is elevated now at baseline (or perhaps from the recent rimadyl?).
I had thought Beau was one of the lucky ones, a Blasto survivor.  He went a month before a skin biopsy diagnosis in 2006, with a HUGE mass of Blasto in his lung.  In that month, he developed skin sores all over, a lame leg, and swollen lymph nodes, but his eyes and nervous system remained unaffected.  With the meds, his lungs returned to normal, and his skin sores healed.  I kept him on itraconazole extra long, hoping he wouldn't be in the 25% who relapse.
He had been diagnosed with Lyme disease around Thanksgiving 2008, was treated with the antibiotic Doxycycline for 30 days, but fever lingered as did decreased interest in food and play.  Blood work 1/30/09 showed the lyme was treated, and the chest xrays were fine, so why the fevers, consistently over 103?  At his appt 2/5/09, his temp was 105.2!!!
I wish I had been checking the urine antigen regularly (his first is in progress now).
This may well be a losing battle for Beau. His whole spine is very tender, either due to the inflammation body-wide, or he may have the blasto in his nervous system.  Hope as I might, I can't imagine that adequate blood levels of Itraconazole will get inside the blasto-mass that his body has tried so hard to wall off...
I don't know how to judge when enough is enough: I suppose when it seems he is not happy at all? Or is it better to treat the inflammation and pain now, have time of walking, tugging, doing the things he loves, and then helping him to rest in peace without letting him go through the decline?  Love him as I do, I don't want to selfishly keeping treating while he continues to weaken and suffer, but it's so hard to know where to draw the line…
Now at times my best friend is breathing 60 /min at rest, up to 120/min when panting at rest (before restarting meds!)  His increased breathing is thought to be due to fevers, but I think he has some metabolic acidosis due to the infection, too, so he's driven to get rid of CO2 with fast breathing.
I can't help but wonder if I am being cruel by helping him keep fighting.  I am crying as I type. Beau is on the bed next to me, looking at me with sad but loving and trusting eyes. The bed shakes from his panting.  He is concerned about my tears and trying to cheer me up by resting his head on my arm and licking my hand.  I need to do what is the right thing for HIM.
I spent until 3 am the night of 2/5 searching the web trying to find more on abdominal masses of Blasto, and where to now order his meds.  It hit me last evening that perhaps my rapid rush to searching is just an attempt to do something, so that I can feel like I CAN do something about his illness.  Perhaps I should be concentrating my efforts more on what the extent of this hidden attack from inside means, and less on busying myself ordering meds that won't arrive for a month…
Folks, I feel like this fear of Blasto, once a pet gets it, never ends.  When Beau got a growth on his gums, I feared Blasto was back (fibrous epulis, removed twice). When he developed haziness of his corneas (lipid dystrophy –appears as if his eye's surface needed a  windshield wiper),  I feared it was Blasto in his eyes.   When he suddenly didn't want to get up in November (and had a fever and hot, tender paw), I knew it was Blasto. But the lyme titer was 120 –he definitely was fighting Lyme…..And now it is Blasto, and yet I am not ready for the diagnosis!!!
Sorry all, to subject you to my sad thoughts.  I know all who read this have likely dealt with the same fears/hopes/worries.  It is hard.
                  Thanks for listening, Lisa Marr and Beau
Hey,  does any one living near a Safeway grocery store know what type of generic itraconazole they sell?  A Seattle friend reports he got 12 wks of txment for his foot fungus for just $8 (?!!!)…..
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Jen

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Re: Beau relapses: Blasto mass in abdomen
« Reply #1 on: February 09, 2009, 07:05:38 AM »

Lisa, I'm so sorry. 
We've been there, and it hurts like nothing else. 
I see nothing wrong with keeping them comfortable.  Advil, Ibuprofen, Tramadol, they work and I don't think they hurt anything.  No sense to be in pain if it can be avoided.

   And I don't recommend that anyone else do it, but I also used 1/2 dose OTC cold medicine with pseudoephedrine to help Dirtbike breathe when she was struggling so hard.  I used them all because for all intents and purposes she was dying, and all I could do was triage and make her comfortable while she fought, if she decided to fight.  She did, and that's all that mattered.  What others do is up to them, and whether I did the right thing, I have no idea.  She's still here.

   I don't know about Itraconazole for $8, but I do know that Pet Health Pharmacy was my only option and they were great, esp. w/overnight delivery.
   Beau's case is different, as they all are.  I think you'll know what to do, and Beau will tell you.  Do your best, hold him tight, and be his best friend.
We'll be thinking of you both- and we cry for all the dogs.
jen
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Wilson3

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Re: Beau relapses: Blasto mass in abdomen
« Reply #2 on: February 09, 2009, 09:48:54 AM »

oh lisa i am sooo sorry!!!
the nightmare doesnt end really sad to say
i feel so bad for you and beau we  knwo the pain all to well
BEAU IS A SURVIVOR! He beat it the 1st time!!! you dont really knwo if it is truely a relaps /was dorment or re exposure doesnt matter really he is sick once more
i totally know the worry you have had before he got this fair
wilsons been have some problems eyes/slight cough throwing up all in small amounts but you wonder is it blasto?
or somthing else or in wilsons case old age in setting in for my dear boy
we live day to day always worring i think somtime our old friends get sick again because I do worry way to much and they think maybe well anyways

find time when it is quite in the house and you and beau go in your room on the bed with a candle talk to him and think about things do not dwell on them the answers will come what you should do never feel bad for what you decide to do
let beau know you will be okay if it is his tiem to go but you hav eto mean it
it isnt easy to do cause the love is so stronge and the fear of the empty feeling is hard letting go isnt always the bad thing either ( i knwoeasy fro me to say right not really i do feel your heart break)
on the other hand alos let beau know you are stronge and willing to do what ever it takes and you stand buy him all the way your inner strenght is what is needed for both of you beau feeds off your strength
i dont know how to put into good words...
i am sooo sorry i calle din sick this morning jumpd on theboard and saw your post my heart acks for you  guys
i willpray for you guys to help you to to find the sttrenght fight
kristin
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gunner

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Re: Beau relapses: Blasto mass in abdomen
« Reply #3 on: February 09, 2009, 11:06:34 AM »

Lisa and Beau,

My heart breaks for you.  I know so well the pain and struggle to decide which tall, putrid glass of poison you are going to have to take.  In the end with Gunner, we decided that her fear of the vet's office was worse than being home with us loving her to the end.  It was truly the hardest thing to do, to watch her decline, but her love and trust and comfort of being home out weighed our agony. 

I am so incredibly sorry for what you are going through and bless Beau's sweet heart for trying to be strong for you.  It doesn't sound to me like he is ready to quit yet.  When they can see past their own pain and discomfort to try to offer comfort to you or to try to do something to please you, they are not ready to quit.  Hang in there until HE's ready.

So here is a thought for you and for others on this board to consider:  The walling off of Blasto.  Itraconazole is the best for a systemic infection of blasto.  Fluconazole is designed to penetrate the harder to get into places like the eyes and central nervous system.  So would there be benafit to switching from Itraconazole to Fluconazole for dogs with walled off Blasto masses?  Would it also be of benafit to those ending the Itraconazole treatment to be on Fluconazole for a few months to maybe get into those hidden places where Itraconazole doesn't pennetrate so well?  Just thinking out loud on this one.

I will be praying for you and Beau,
Joyce
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weluvmoose

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Re: Beau relapses: Blasto mass in abdomen
« Reply #4 on: February 09, 2009, 02:21:06 PM »

I am so sorry for what you are going through - we will be praying for you...you can only do the best you can and try and not let fear or guilt get the best of you.  Dogs are fun-loving, optimistic and forgiving creatures and I think they inspire that in us all whether their lives are long or short - our best to you...
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lisamarr

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Re: Beau relapses: Blasto mass in abdomen
« Reply #5 on: February 09, 2009, 06:39:23 PM »


I just got a call with Beau's MiraVista Urine antigen: Strong positive, 33.03
WOW. 
Beau's actually eating better today (day 3 Itraconazole). We'll just go day by day...
Thanks for all your support! Lisa Marr and Beau
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evayola

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Re: Beau relapses: Blasto mass in abdomen
« Reply #6 on: February 09, 2009, 07:35:36 PM »

Lisa,

Like the others I too am so sorry for what Beau has to go through. Joyce had mentioned fluconazole and I personally think it would be worth a shot considering it is in his abdomen and the flucon penetrates those hard to reach places better than the itra. The fluconazole can also be found cheaper than the itra. I get Marge's for $43/mo. Marge is on flucon again even though her titer revealed a negative result. She has been on the flucon on/off since June 07. It sounds crazy that I am still treating her but I have my suspicions that it is still lingering in her somewhere. We go to the vet tomorrow to check her bloodwork and do xrays on her front paw again.

Beau's #'s is high but it is still lower than Marge's was. Marge tested at 45 initially. I highly recommend doing the miravista test that will reveal the absorption levels of the meds whether its itra or flucon. The best that you can do for Beau is love him and comfort you. I am sure you already are doing that. He is a strong boy and will fight his butt off. THat is great to hear that he is eating good. Keep us posted.

Eva
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jiggasmom

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Re: Beau relapses: Blasto mass in abdomen
« Reply #7 on: February 12, 2009, 02:49:02 PM »

I am so sorry to read about Beau. Jigga and I will hold paws and pray for him. Good luck! He beat it once he can beat it again.
It is terrifying. Jigga is 3 months in treatment and for the most part he seems to be doing great but every day I look at him and wonder is it still in there lurking and we just don't know. The weather was great yesterday we took him for a 2 mile walk and last night he was panting so heavy and fast I couldn't sleep I just watched him until he fell asleep. Every sneeze, every cough, every pant I fear that it is never going away.
But we all must be strong and be positive.
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lisamarr

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Re: Beau relapses: Blasto mass in abdomen
« Reply #8 on: February 22, 2009, 08:13:17 PM »


Beau has been on meds for 2 wks now. Finally, these past 2 days, his breathing has calmed down. And today, he actually ate dry food! Although I can't trick myself into believing that he will be cured of Blasto (that the abdominal mass will actually disappear), I can hope that the meds will allow him more time of pain free play....I fully intend to keep him on antifungals for as long as he survives.

This is a relapse, not a new infection. Blastomycosis is seeded in the abdominal cavity only after pulmonary/disseminated blasto (what he had in 2006).  But if he could handle itraconazole for 10-11 months then, I am hoping he won't have side effects this time around down the road. Atleast now I am not walking each morning thinking that this day may be his last ---he seems to be stabilizing !
                  Lisa marr and Beau
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jiggasmom

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Re: Beau relapses: Blasto mass in abdomen
« Reply #9 on: February 27, 2009, 03:37:57 PM »

that is good to hear that he seems to be doing well. Stay positive and keep us posted! Jigga and I will hold paws and pray for you guys!
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Judy

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Re: Beau relapses: Blasto mass in abdomen
« Reply #10 on: February 27, 2009, 06:37:15 PM »

I am so glad that he is stabilizing...I really think you should consider the mira vista level for the fluconazole (I know they have itraconazole), and do it around 22-23 hours after the last dose so you know how much is in his blood to take care of the blasto.   Judy
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Judy

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Re: Beau relapses: Blasto mass in abdomen
« Reply #11 on: February 27, 2009, 09:11:15 PM »

Did the mass have pancreatic tissue in it? Was it a walled off area pure with blasto? See if you can get a copy of the path report... This brings up the question of small lumps, cysts that many of our dogs have. Particularly, Francie has about three little fatty cysts, one on neck, one below jaw and one on hind quarters. I've always thought that blasto had laid dormant for a time, and still wonder if these areas have blasto. I didn't allow the vet to aspirate the one four years ago, just watched it... but it just makes me wonder if the body is walling off the blasto for a period of time, then with an insult it can't do it any more and it comes out as the disease.... no need to do it now, but when you can that might help our ongoing learning to help everyone. Judy
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Jen

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Re: Beau relapses: Blasto mass in abdomen
« Reply #12 on: February 28, 2009, 07:20:12 AM »

So glad to hear he's eating, esp. dry food.  Going through it a second or even another time is everyone's nightmare, and it really helps to see that relapses can be fought.
Thanks for keeping us posted.
Congratulations -
jen
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lisamarr

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Re: Beau relapses: Blasto mass in abdomen
« Reply #13 on: March 02, 2009, 03:35:37 PM »

   I'm keeping Beau on Itraconazole rather than switching to Fluconazole.  My understanding of the differneces between the two in terms of where they distribute is the following:
   Itraconazole doesn't cross the blood/brain barrier very well. Hence, it is difficult to get levels of itraconazole in the nervous system (brain, eyes, spinal cord, etc) high enough to kill the yeast. In a dog with no nervous system involvement, itraconazole is the drug of choice ---fewer side effects during length of treatment.
   Fluconazole has a better penetration into nervous tissue, so is the drug of choice to treat Blastomycosis when the infection is in the nervous system.


I have the ultrasound report, and it is rather vague in comparison to the human reports! It doesn't give the size of the mass. It suggests it may be associated with the pancreas, but also suggests it may be peritoneal (within the abdominal cavity, but not part of another organ).  The biopsy was of fluid surrounding the mass, and the pathologist report just states that yeast consistent in appearance with Blasto is present (blastomyc. dermatides has a very specific appearance --double walls).

Next wk it will be time for more blood work. They want to do another ultrasound, but given that I doubt it will chance his treatment at all, I am going to suggest we wait another couple of months...

He is doing much better now after 3+ wks on meds: the rapid breathing is gone, his appetite is improved, the fevers are rare, and he wants to play.  I'm feeling more hopeful, even if I have to keep him on antifungals forever!
              Thanks, all - Lisa and Beau
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Judy

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Re: Beau relapses: Blasto mass in abdomen
« Reply #14 on: March 05, 2009, 12:01:17 PM »

Sounds good, you may want to ask about an UltraSound in a few months to see if the mass has increased or decreased in size, that might help with the differentiation of cancer vs. blasto. Judy
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