I've thought much about what Ginger said about "Relapse vs. Re-exposure".
What we've learned is that most dogs don't even get it when exposed.
This is supposedly due to lots of factors, but one in particular being that the ones who do get infected may have a compromised immune system at the time.
We treat it for 6 months or more in some cases, and how many of us really know whether it's actually gone without antigen testing? Or whether they've been re-exposed?
In October I was very afraid to take Dirt off the Itra, even when the vet said it was ok, so I "tapered" her dose for at least another month. She has been ***knockswood*** symptom-free for 9 mos. now, but I have given her what I considered a "prophylactic dose", a pill every two days, for about 2 weeks just because she had been slogging through the swamp and chasing (okay, eating) beavers. I
cannot allow her to come down with another full-blown case.
For me, the important thing will be recognizing it and not allowing it to take hold like the 1st time. It's possible that as the Blastomycosis in Dogs paper states, some may need to keep some Itra floating around in their system at all times to prevent relapse.
Link here:
http://72.14.205.104/search?q=cache:eKbrO5FcPn0J:www.miravistalabs.com/Files/pdf/BlastomycosisinDogs2007.pdf+blastomycosis+in+dogs+miravista&hl=en&ct=clnk&cd=1&gl=us"
In some cases that relapse despite four to six months of itraconazole, itraconazole suppressive therapy given two or three times weekly may prevent recurrence. The antigen test may be useful for diagnosing relapse, indicated by the two spikes in (Figure 3)."
We really don't know anything for sure.
It's entirely possible that some dogs may need a suppressive dose their entire lives.
If that's what's necessary, I could live with it.
Perhaps vets need to re-think the idea that it can be completely cleared from the body in 6 or 12 months, or ever, in some animals.
jen