I'm sorry to hear about your brother, and now it hit in your family again. Well I hope they find what it is thats causing it, it may something in the house or around the house. I myself have had blasto twice, the first time, it was in my lungs, I started getting a cold, and it got worse, then they said I had the flu, it got worse, then it was bronchitis, it just kept getting worse, I actually thought I was dying. I couldn't sleep, eat, had fevers at night, coughing nonstop, it was awful, no amount of antibiotics would help. They finally put me in the hosp. for some test and they found blasto, I had to take treatment for a month, then the same time the following year, I got it again, this time in my brain, they found lesions on my brain, this time they put in the hosp. immediately, I underwent treatment for 6 months. The funny thing is they were never able to tell me where I got it. At that time, it was a rare disease, theres alot more information on it now than 10 yrs ago. All I know is they said that you could get it from old rotting wood, decomposed vegetation, and bat and rodent droppings, and probably from things like mold. I know at that time, I lived with my grandfather, and he had a old chicken house behind the house, and I was looking in it one day, he had alot of old stuff stored in it. Thats the only thing I could think of. But tell your sister to get her husband more treatment, if he's still having symptoms, if it gets worse its alot harder to treat, and to be careful because it can come back later, I know...