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[Jen]

   I still cannot remember the exact place where I read that Oral Itraconazole (Not the solution) should be given with a bit of fat, but I have searched for as much information as I could find.  Lisa posted earlier a very good explanation of Itraconazole and why it is better absorbed along with a fatty food.  That's the most informative I've seen.  Lisa, if you're able, could you post it again?  Thx.

   I was unable to find any research on fat being dangerous to animals with Blastomycosis or that fat feeds blasto.  I'd be interested to see an article about it if anyone has one.

The articles I found specifically mentioning fatty food and Itra were mostly professional sites that required membership/payment to view articles.  The links are included below, along with direct quotes from some other links.  It's not the kind of research I'd like to have seen, but it's all I could find.


www.future-drugs.com/doi/abs/10.1586/14787210.1.4.531
(Not a free article)
Itraconazole (Sporanox®) in superficial and systemic fungal infections
The capsule formulation of oral itraconazole is well absorbed when administered with food, especially fatty food. [20,21] . The. absorption is dependent on ...

linkinghub.elsevier.com/retrieve/pii/S1055937X00800031
(not a free article)
PII: S1055-937X(00)80003-1
blastomycosis in dogs with no untoward effects. 36. Itraconazole ... in an enhanced absorption when administered with a fatty meal.

http://www.theveterinarian.com.au/clinicalreview/article294.asp
“Itraconazole should be administered with a fatty meal and to maximise absorption, concurrent administration of drugs that decrease stomach acidity should be avoided. For cats, the capsules may be opened and mixed with food.”

http://www.dcavm.org/03jan.htm
For wide-spread infections: systemic therapy.
1. Oral ketoconazole (Nizoralâ; 5 to 10mg/kg Q24h for 21 to 28 days)
2. Oral itraconazole (Sporanoxâ; 10mg/kg Q24h for 21 to 28 days)
3. A low-dose regimen of ketoconazole (5mg/kg Q24h for 10 days, followed by 5mg/kg Q48h for 10 doses) has been reported to be successful in the majority of cases, and lessens the expense of therapy.
a. Give these drugs with food (fatty meal). Use caution in dogs with hepatic disease.
Pre-screen liver enzymes in old/debilitated animals.

http://www.emedicine.com/derm/topic152.htm
Itraconazole:
Caution in hepatic insufficiencies; generally well tolerated, but approximately 12% of patients show adverse effects, which primarily include GI abnormalities; hepatobiliary dysfunction was observed; take with fatty food, which increases absorption in alimentary tract.

[Wilson3]

thank you for posting what you did find 
i am going to print this and take it in to all the different vets here
the stuff they showed me and the others here that have had blasto  all says that sugars/fatty foos feed yeast
and should not be given they also told us that we shouldnt be feeding fatty foods in the first place but we all here us the holistic way of healing as often as we can and diet is the biggest part and the vets say that some carbs but very few, high proteins

thanks again for posting this i really dont understand why vets all seem to think something different my dogs never get any fatty foods and no grains they eeat a lot of raw meat and vegs fruits is where they get there natural sugars from
so har dto really knowwhat is best to many different answers
i cannot wait to show them this and see what they respond
thansk again

[Wilson3]

this is what kind of diet  we followed kind of but this one is printed for peopel looking for the one for dogs
the only really big difference is dogs are meat eaters so that is the bulk of there diet meat and
am still amazed they say to feed fat to an animal i am going to call my vet now

Alternative treatment

Alternative treatment for fungal infections focuses on creating an internal environment where the fungus cannot survive. This is accomplished by eating a diet low in dairy products, sugars, including honey and fruit juice, and foods like beer that contain yeast. This is complemented by a diet consisting, in large part, of uncooked and unprocessed foods. Supplements of vitamins C, E, A-plus, and B complex may also be useful. Lactobacillus acidophilus and Bifidobacterium will replenish the good bacteria in the intestines. Some antifungal herbs, like garlic (Allium sativum), can be consumed in relatively large doses and for an extended period of time in order to increase effectiveness. A variety of antifungal herbs, such as myrrh (Commiphora molmol), tea tree oil (Melaleuca spp.), citrus seed extract, pau d'arco tea (Tabebuia impetiginosa), and garlic may also be applied directly to the infected skin

[Wilson3]

jen thanks for the info the vets here have looked over the sites and allthe info they still feel that fatty greasy foods are not good to feed any dog much less a dog with blasto i beleave them 4 dogs here all where very very sick almost died all fallowed the "NO" fat diet and all are still here and off meds and the holistic vets all say fatty greasy foods feed yeast i wish they would put somthing on line about it all i know is wilson should not be here now and he is some how he is and the othe r3 dogs they to
i am going to keep reserching this
thanks for finding the sights
wilson3

[Jen]

While I agree that it's not good to feed fat or greasy foods as a matter of course, the Itraconazole remains a fat-soluble medication.  Even the oral suspension is Itra in an emulsion of fat.  Just like fat-soluble vitamins, some things need it in order to be metabolized.

 All I knew was that DB was starving because she would eat absolutely nothing, she would fight the pill in any kind of food or even in the Ensure. If a spoonful of margarine did the trick I was all for it. 

None of the sites explained it the way I would have preferred, but it was the best I could find.  I still don't understand why I can't find the site that went into detail about the lack of digestive enzymes due to vomiting, and making sure they had something fatty in the stomach. 

Perhaps someone else who is dosing the same way will clarify??