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[Pandomania]

I have read a couple posts here stating that the compounded form has lower absorption rates than that of the round micro bead capsule form of Sporanox.  Any links to studies out there?  Should increase fat intake with the generic compounded form to better metabilize the drug.  Pando says he will bong the drug if need be:)

Share first hand experiences (symptoms and outcomes) with pets that have made the transition from Sporanox to the compounded form.

[Jen]

We used compounded Itra from Pet Health Pharmacy in AZ from the beginning, 150 mg./day caps.  I did find a study (which I can't find again) that said to give it with a fatty food, as it is better metabolized with something like that in the stomach. She hated peanut butter, and was eating nothing but Ensure Plus (force-fed) and maybe some Little Cesar dinners (try keeping a dog that size on LC dinners- waay expensive).
 I finally stuck the capsule in a tsp. of margarine (Country Crock!) which she really liked.

In order to take her mind off the capsule being in it, I would smear some on her snoot at the same time.  She would swallow the pill quickly because she was pre-occupied with licking margarine off her nose.
 Even after treatment she still asks for her butter, but that's not happening.  I think it also made her feel special, as the other dogs didn't get any.

One odd thing - Millie would sniff the spoon w/ butter and Itra, and run away.  Obie would've eaten it if I let him, but Millie was scared of it.  As you can see from prev. posts, DB's outcome has been excellent, soooo...

jen

[Wilson3]

my vet had said there really is not a difference just some people my perfer one over the other like brands of food
also ssaid that when feeding high fatty foods it feeds the yeast that blasto turns into in the body high protein i was told dogs would eat meat inthe wild
i dont really know for sure i just lknow what worked for us
the other people i know where told the same thing from there vets

[evayola]

We had Marge on the tablet form of fluconozole from CVS but it was super expensive. We were paying $500+/ month. Jen suggested Pet Health Pharmacy in AZ so we ordered some up and it was only $23/month. We were super excited about it but after two days of taking it, Marge wouldnt eat and was very lethargic. The vet said that the compounded form was way too hard on her stomach so we had to switch back to tablet form. Luckily, I called around and found it at WalMart for only $45/month! I told my vet about that and she is in shock because of what I was paying at CVS. marge did a total turnaround once we put her back on tablet form and was back to eating and running around. I think it all just depends on the dog.

[Wilson3]

i just got doen asking the the people in the pharm here at the hospital and they said there is no difference only would they perfer in form the only difference is the filler part of the med not the drug it self (color  shape )
so that is why some my react to  to some brands differently but the drug part is the same hope this makes sence

[Pandomania]

Thanks for all of the replies.  I called the pharmacy in AZ (Road RUnner) and so did our vet.  They said that as long as you give the itra with food it should absorb 100%.  It will absorb less if it is given on an empty stomach.  There is a difference, if you give your dog the liquid itra, that does require an empty stomach. 

[Wilson3]

found this kind of interesting
http://www.veterinarypartner.com/Content.plx?P=A&A=520&S=2&EVetID=900000012

[Pandomania]

Thanks Wilson, that website you gave really spells it out nicely. 

[Wilson3]

this site talks about the dose
http://www.merckvetmanual.com/mvm/htm/bc/190503.htm#aItraconazole:

[Wilson3]

i found this about does
   
TABLE 11: Dosages of Antifungal Medications 
 
   
 Drug Dosage
Griseofulvin   
Microsize 25-60 mg/kg, PO, bid 
Ultramicrosize 2.5-15 mg/kg, PO, bid 
Ketoconazole 10 mg/kg, PO, sid; 20 mg/kg, PO, every 48 hr

Itraconazole 5-10 mg/kg, PO, sid 
Fluconazole 10-20 mg/kg, PO, bid 
Amphotericin B Dogs: 0.25-0.75 mg/kg, IV, 3 times/wk to total cumulative dose of 4-8 mg/kg or until azotemia develops Cats: 0.1-0.25 mg/kg, IV, 3 times/wk to cumulative dose of 4-6 mg/kg
Flucytosine 25-50 mg/kg, PO, tid-qid 
Potassium iodine Dogs: 40 mg/kg, PO, sid-bid with food Cats: 20 mg/kg, PO, sid-bid with food
 
   

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